DIET-ASSOCIATED INFLAMMATION, PHYSICAL ACTIVITY, AND HEALTH-RELATED OUTCOMES IN ULCERATIVE COLITIS

Individuals diagnosed with Ulcerative Colitis (UC) often seek complementary lifestyle methods, such as diet and physical activity, to self-manage disease symptoms respond the psychosocial challenges of living chronic illness. The Energy Adjusted Dietary Inflammatory Index (E-DIITM) measures inflammatory potential one’s food intake has never been studied among UC population. This study aimed test associations between E-DII scores, related health outcomes. Data obtained from participants in IBD Partners e-cohort who self-reported (n=2,052) were analyzed using a cross-sectional, secondary data analysis. Patients had undergone UC-related surgery excluded. collected through National Cancer Institute frequency questionnaire converted into an score. Physical activity Godin-Shephard Leisure Time Activity Index. Outcome variables included Simple Clinical (SCCAI), Short Bowel Disease Questionnaire (SIBDQ), PROMIS domains anxiety, depression, fatigue, sleep disturbance, satisfaction social role. Multivariable regression models controlled for age, sex, BMI, race, education, diet, smoking status, medication class, duration. A higher score (indicating pro-inflammatory dietary potential) was significantly associated increased (β=0.166; p<0.001), reduced health-related quality life (β= -0.056; anxiety (β=0.342; p=0.006), depression (β=0.408; p=0.004), fatigue (β=0.386; p=0.005), disturbance (β=0.339; p=0.003), decreased role -0.370; p=0.004). inversely -0.108; -0.025; p=0.001), -0.058; -0.019; p=0.008), while positively IBD-related (β=0.005; p<0.001) (β=0.063; p<0.001). benefit outcomes, excluding greater strenuous exercise intensity than moderate or mild intensities. For all interaction effects not significant. These findings suggest that anti-inflammatory are each methods may contribute decreases well improvements life, sleep, Such modalities aid managing systemic localized inflammation reduce burden on daily living.